The general perception was to avoid photochemistry altogether as it imposed too many insurmountable issues to bring the molecule to the market. Photochemistry was only considered when there was no alternative available, such as in the production of vitamin D and rose oxide as prime examples. Nevertheless, this time the moment could be right for a definitive breakthrough of synthetic photochemistry in the industry. The first reason for this statement is the rapid uptake and maturation of photocatalysis in both academia and industry, allowing researchers to completely rethink the assembly of organic molecules.
(40) It is remarkable to see how fast companies have established small groups of experts to investigate the potential impact of photocatalysis in their synthetic programs. (41) Second, the tremendous evolution of light-emitting diode (LED) technology has resulted in the development of monochromatic, energy efficient, durable, and high intensity light sources, reducing the effective costs of photons for photochemical applications. (42) And third, various advanced photochemical reactor technologies have been developed in recent years, which show great promise to carry out photochemical processes ranging from laboratory to production scale. (43,44) Several companies have focused on developing and commercializing standardized equipment to carry out photocatalytic transformations on different scales. However, it is important to note that the application of photocatalysis in organic synthesis is not a recent invention. (4) On the contrary, several important contributions were made already decades ago.
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